One thing talk therapy and manual therapy have in common is that they both deal with unresolved issues. Typically, talk therapy deals with how issues are stuck in time, or in the mind, whereas manual therapy deals with how issues are stuck in space, or in the physical body. Often the two are interconnected.
Similar to the underlying mechanics of psychology, the unresolved issue sits at the center of the complex surrounded by a web of compensation and/or adaptation.
Biopsychosocial is an updated mind-body continuum that additionally includes social factors. Social factors are contextual factors that can have many nuances.